Aptivus 250mg 120caps 

Boehringer Ingelheim 

1,300.10 

1,287.23 

1,000.08 

Active Ingredient: tipranavir; Major Inactive Ingredients: dehydrated alcohol, polyoxyl 35 castor oil, propylene glycol, mono/diglycerides of caprylic/capric acid and gelatin. 

APTIVUS is a medicine called a “protease inhibitor” that is used to treat adults with Human Immunodeficiency Virus (HIV). APTIVUS blocks HIV protease, an enzyme which is needed for HIV to make more virus. When used with other anti-HIV medicines, APTIVUS may reduce the amount of HIV in your blood and increase the number of CD4+ cells. Reducing the amount of HIV in the blood may keep your immune system healthy, so it can help fight infection. APTIVUS is always taken with NORVIR® (ritonavir) and at the same time as NORVIR. When you take APTIVUS with NORVIR, you must always use at least 2 other anti-HIV medicines. 

PATIENTS TAKING APTIVUS, TOGETHER WITH 200 MG NORVIR® (RITONAVIR), MAY DEVELOP SEVERE LIVER DISEASE THAT CAN CAUSE DEATH. IF YOU DEVELOP ANY OF THE FOLLOWING SYMPTOMS OF LIVER PROBLEMS, YOU SHOULD STOP TAKING APTIVUS/RITONAVIR TREATMENT AND CALL YOUR DOCTOR RIGHT AWAY: TIREDNESS, GENERAL ILL FEELING OR “FLU-LIKE” SYMPTOMS, LOSS OF APPETITE, NAUSEA (FEELING SICK TO YOUR STOMACH), YELLOWING OF YOUR SKIN OR WHITES OF YOUR EYES, DARK (TEA-COLORED) URINE, PALE STOOLS (BOWEL MOVEMENTS), OR PAIN, ACHE, OR SENSITIVITY ON YOUR RIGHT SIDE BELOW YOUR RIBS. IF YOU HAVE CHRONIC HEPATITIS B OR C INFECTION, YOUR DOCTOR SHOULD CHECK YOUR BLOOD TESTS MORE OFTEN BECAUSE YOU HAVE AN INCREASED CHANCE OF DEVELOPING LIVER PROBLEMS. Do not take APTIVUS if you: • are allergic to tipranavir or any of the other ingredients in APTIVUS. • are allergic to ritonavir (NORVIR®) • have moderate to severe liver problems • take any of the following types of medicines because you could have serious side effects: o Migraine headache medicines called “ergot alkaloids”. If you take migraine headache medicines, ask your doctor or pharmacist if any of them are “ergot alkaloids”. o Halcion® (triazolam) o Hismanal® (astemizole) o Orap® (pimozide) o Propulsid® (cisapride) o Seldane® (terfenadine) o Versed® (midazolam) o Pacenone® (amiodarone) o Vascor® (bepridil) o Tambocor® (flecainide) o Rythmol® (propafenone) o Quinaglute dura® (quinidine) Tell your doctor about all of your medical conditions, including if you: • have liver problems or are infected with hepatitis B or hepatitis C. These patients may have worsening of their liver disease. • are allergic to sulfa medicines. • have hemophilia. APTIVUS may cause increased bleeding. • have diabetes. APTIVUS may worsen your diabetes or high blood sugar levels. • are pregnant or planning to become pregnant. It is not known if APTIVUS can harm your unborn baby. You and your doctor will need to decide if APTIVUS is right for you. If you take APTIVUS while you are pregnant, talk to your doctor about how you can be in the Antiretroviral Pregnancy Registry. • are breast-feeding. Do not breast-feed if you are taking APTIVUS. You should not breast-feed if you have HIV because of the chance of passing the HIV virus to your baby. Talk with your doctor about the best way to feed your baby. • are using estrogens for birth control or hormone replacement. Women who use estrogens for birth control or hormone replacement have an increased chance of developing a skin rash while taking APTIVUS. If a rash occurs, it is usually mild to moderate, but you should talk to your doctor as you may need to temporarily stop taking either APTIVUS or the other medicine that contains estrogen or female hormones. Tell your doctor about all the medicines you take including prescription and nonprescription medicines, vitamins and herbal supplements. APTIVUS and many other medicines can interact. Sometimes serious side effects will happen if APTIVUS is taken with certain other medicines (see “Who should not take APTIVUS?”). • Some medicines cannot be taken at all with APTIVUS. • Some medicines will require a change in dosage if taken with APTIVUS. • Some medicines will require close monitoring if taken with APTIVUS. Women taking birth control pills need to use another birth control method. APTIVUS makes birth control pills work less well. Know all the medicines you take and keep a list of them with you. Show this list to all your doctors and pharmacists anytime you get a new medicine you take. They will tell you if you can take these other medicines with APTIVUS. Do not start any new medicines while you are taking APTIVUS without first talking with your doctor or pharmacist. You can ask your doctor or pharmacist for a list of medicines that can interact with APTIVUS. 

Take APTIVUS exactly as your doctor has prescribed. You should check with your doctor or pharmacist if you are not sure. You must take APTIVUS at the same time as NORVIR® (ritonavir). The usual dose is 500 mg (two 250 mg capsules) of APTIVUS, together with 200 mg (two 100 mg capsules or 2.5 mL of solution) of NORVIR, twice per day. APTIVUS with NORVIR must be used together with other anti-HIV medicines. APTIVUS comes in a capsule form and you should swallow APTIVUS capsules whole. Do not chew the capsules. • Always take APTIVUS with food. • Do not change your dose or stop taking APTIVUS without first talking with your doctor. • If you take too much APTIVUS, call your doctor or poison control center right away. • If you forget to take APTIVUS, take the next dose of APTIVUS, together with NORVIR® (ritonavir), as soon as possible. Do not take a double dose to make up for a missed dose. • It is very important to take all your anti-HIV medicines as prescribed and at the right times of day. This can help your medicines work better. It also lowers the chance that your medicines will stop working to fight HIV (drug resistance). • When your APTIVUS® supply starts to run low, get more from your doctor or pharmacy. This is very important because the amount of virus in your blood may increase if the medicine is stopped for even a short period of time. The HIV virus may develop resistance to APTIVUS and become harder to treat. You should NEVER stop taking APTIVUS or your other HIV medicines without talking with your doctor.